tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Names and Identifiers

Name	tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate
Synonyms	4-(4-BOC-PIPERAZINYL)PHENYLBORONIC ACID PINACOL ESTER 4-[4-(N-Boc)piperazin-1-yl]phenylboronicacidpinacolester 4-[4-(N-Boc)piperazin-1-yl]phenylboronic acid pinacol ester 4(N-TERT-BUTOXYCARBONYLPIPERAZINE)BENZENEBORONIC ACID PINACOL ESTER 4-Piperazin-1-ylbenzeneboronic acid pinacol ester, N4-BOC protected 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER t-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazinecarboxylate tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate 4-[4(4,4,5,6-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]piperazine-1-carboxylic acid tert-butyl ester 4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl]phenylpiperazine-1-carboxylic acid tert butyl ester Tert-butyl4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)tetrahydro-1(2H)-pyrazinecarboxylate tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate TERT-BUTYL 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE 1-Piperazinecarboxylic acid, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-dimethylethyl ester
CAS	470478-90-1
InChI	InChI=1/C21H33BN2O4/c1-19(2,3)26-18(25)24-14-12-23(13-15-24)17-10-8-16(9-11-17)22-27-20(4,5)21(6,7)28-22/h8-11H,12-15H2,1-7H3
InChIKey	ZMAVVXGWEHZLDW-UHFFFAOYSA-N

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Physico-chemical Properties

Molecular Formula	C21H33BN2O4
Molar Mass	388.31
Density	1.11
Melting Point	157 °C
Boling Point	501.7±45.0 °C(Predicted)
Flash Point	257.2°C
Vapor Presure	3.4E-10mmHg at 25°C
pKa	3.06±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.536
MDL	MFCD06411544

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Risk and Safety

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
Hazard Note	Harmful

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.575 ml	12.876 ml	25.753 ml
5 mM	0.515 ml	2.575 ml	5.151 ml
10 mM	0.258 ml	1.288 ml	2.575 ml
5 mM	0.052 ml	0.258 ml	0.515 ml

Last Update：2024-01-02 23:10:35

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Reference Information

Application

4-(4-Boc-1-piperazinyl) benzeneboronate Ester is an important raw material for Suzuki cross-coupling reaction, the conjugate addition reaction can be carried out with a carboxyl compound containing a,β unsaturated bond, and is widely used in the field of pharmaceutical and chemical industry.

preparation

5-bromo-2-(4-Boc-piperazin-1-yl) pyrimidine, diboronic acid cyano alcohol ester [B2(pin)2] for boron reagent, K3PO4 · 7H2O for alkali, in the chlorine (2-dicyclohexylphosphino -2 ',4',6 '-triisopropyl-1, 1'-biphenyl)[2-(2 '-amino -1,1'-biphenyl)] palladium (II)(Xphos-Pd-G2) synthesis of 4-[4-(N-BOC)] catalyzed by 2-dicyclohexyl phosphorus -2 ',4',6 '-triisopropylbiphenyl (Xphos) piperazine-1-yl] Phenylboronic acid derivative. The synthesis reaction formula is as follows:

Last Update：2024-04-09 20:45:29

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate

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Product Name: 4-(4-Tert-Butoxycarbonyl-Piperazinyl)Phenylboronic Acid, Pinacol Ester Visit Supplier Webpage Request for quotation
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tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate

CAS: 470478-90-1

Molecular Formula: C21H33BN2O4

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Names and Identifiers

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Physico-chemical Properties

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Risk and Safety

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Preparation solution concentration reference

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Reference Information

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tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate Request for Quotation

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate

CAS: 470478-90-1

Molecular Formula: C21H33BN2O4

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Names and Identifiers

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Physico-chemical Properties

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Risk and Safety

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Preparation solution concentration reference

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate - Reference Information

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tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate